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FlyMind · whole-brain connectomics & living wiring diagram

FLYMIND

In 2024 the FlyWire consortium published the first complete wiring diagram of an adult animal's brain: every neuron of a fruit fly and every synapse between them, traced from electron microscopy. FlyMind is a specimen viewer for that map, 139,255 neurons and about 50 million connections rendered from the published counts, with $FLYMIND on Robinhood Chain as its attestation.

Anatomical specimen

One point for ten neurons. The shape is a schematic model built from the published region layout, not the dataset itself; the counts on the right are FlyWire's. Drag to rotate.

neurons
139,255whole adult brain, FlyWire 2024
synapses
~50 millionchemical synapses, EM traced
cell types
8,453annotated in the same release
wiring
~149 mof neurites in one brain
Specimen attestation · $FLYMIND · Robinhood Chain
soon
PonsChart
The connectome · FlyWire consortium · Nature, October 2024

What does a whole brain look like when every wire is known?

For a century neuroscience worked from samples: a few neurons stained, a few circuits traced. In 2024 a consortium led from Princeton, with hundreds of labs and volunteer proofreaders, finished the map of an entire adult brain, that of a female fruit fly. The raw material was a brain sliced into thousands of sections and imaged with electron microscopes; the segmentation was done by AI and corrected by people, synapse by synapse.

"A fly brain is smaller than a poppy seed. It still took about a decade, machine learning, and hundreds of people to read all of it."the scale of the task
Epoch 01 / Imaging

A whole brain sliced and photographed

The FAFB volume: one adult female fly brain cut into thousands of ultrathin sections and imaged with serial-section electron microscopy at nanometre resolution, published in 2018 as an open dataset.

2018
Epoch 02 / Segmentation

Machine learning draws the neurons

Convolutional networks traced every neuron through the image stack. FlyWire opened the result to the community as a proofreading platform, where people fix merges and splits the model got wrong.

2020 to 2023
Epoch 03 / Larva

The larval brain, complete

A related effort finished the connectome of a fly larva first: 3,016 neurons and about 548,000 synapses, published in 2023 as the first full brain wiring diagram of an insect at any stage.

2023
Epoch 04 / Whole adult brain

139,255 neurons, every synapse

The adult connectome and its cell-type atlas appeared together in Nature: 139,255 neurons, about 50 million synapses, 8,453 cell types, released openly for anyone to query.

2024
Signal path · from photon to wing

How a fly sees a threat and leaves

The connectome makes it possible to follow a signal across the whole brain instead of stopping at a region boundary. The route below is the anatomy the map traces for vision.

01 · retina

Photoreceptors

Each of the compound eye's units carries photoreceptor cells that turn light into membrane voltage.

02 · lamina and medulla

Optic lobe layers

The optic lobes, a large share of all neurons in the brain, sort the image by contrast, motion and direction in repeated columns.

03 · lobula plate

Motion detectors

Wide-field neurons integrate motion across the visual field; a looming shape reads as an approaching object.

04 · descending neurons

Down to the body

Descending neurons carry the decision from the brain to the ventral nerve cord, where the legs and wings are driven.

Anatomical integration

Slice inspector

Move through the specimen front to back. Each slice is a cross-section of the schematic model above, so what you see is where the regions sit, not a micrograph.

Staining mode

Anterior to posterior

Subject dossier

The specimen and its sources

Specimen

Drosophila melanogaster, adult female

The FAFB brain: one individual, imaged whole. The connectome describes this one fly; a second brain, a male, is being mapped to compare.

Method

Serial-section EM, AI segmentation, human proofreading

Sections at nanometre resolution, neurons traced by convolutional networks, corrections by hundreds of proofreaders including volunteers, synapses detected automatically.

Access

Open data

The connectome is public and queryable. FlyMind draws only the published counts and region layout; nothing here is measured by us.

flywire.ai ↗

Layer 2 protocol · specimen attestation

$FLYMIND on Robinhood Chain

$FLYMIND is an ordinary Pons coin. It has no claim on the data, the labs, or the fly. What it does is give this specimen viewer an address on Robinhood Chain: the contract below is the token, the numbers above are the consortium's, and the two are kept apart on purpose.

settlementRobinhood Chain · 4663
launchpadPons
contractsoon
specimenFAFB, adult female